NASA's first attempt to fly its "Ingenuity" helicopter on Mars was a success, marking what the space agency says is the first powered, controlled flight by an aircraft on another world. The BBC reports: The space agency is promising more adventurous flights in the days ahead. Ingenuity will be commanded to fly higher and further as engineers seek to test the limits of the technology. The rotorcraft was carried to Mars in the belly of Nasa's Perseverance Rover, which touched down in Jezero Crater on the Red Planet in February.

The demonstration saw the Mars-copter rise to just over 3m, hover, swivel 96 degrees, hover some more, and then set down. In all, it managed almost 40 seconds of flight, from take-off to landing. Getting airborne on the Red Planet is not easy. The atmosphere is very thin, just 1% of the density here at Earth. This gives the blades on a rotorcraft very little to bite into to gain lift. There's help from the lower gravity at Mars, but still -- it takes a lot of work to get up off the ground. Ingenuity was therefore made extremely light and given the power (a peak power of 350 watts) to turn those blades extremely fast - at over 2,500 revolutions per minute for this particular flight. Control was autonomous. The distance to Mars - currently just under 300 million km -- means radio signals take minutes to traverse the intervening space. Flying by joystick is simply out of the question.

Ingenuity has two cameras onboard. A black-and-white camera that points down to the ground, which is used for navigation, and a high-resolution colour camera that looks out to the horizon. Sample navigation images sent back to Earth revealed the helicopter's shadow on the floor of the crater as it came back in to land. Satellites will send home more pictures of the flight over the next day. There was only sufficient bandwidth in the orbiters' first overflight to return a short snatch of video from Perseverance, which was watching and snapping away from a distance of 65m. Longer sequences should become available in due course.

An anonymous reader shares a report: Now a second wave of Covid-19 has struck India, and the middle class dreams of tens of millions of people face even greater peril. Already, about 32 million people in India were driven into poverty by the pandemic last year, according to the Pew Research Center, accounting for a majority of the 54 million who slipped out of the middle class worldwide. The pandemic is undoing decades of progress for a country that in fits and starts has brought hundreds of millions of people out of poverty. Already, deep structural problems and the sometimes impetuous nature of many of Mr. Modi's policies had been hindering growth. A shrinking middle class would deal lasting damage. "It's very bad news in every possible way," said Jayati Ghosh, a development economist and professor at the University of Massachusetts Amherst. "It has set back our growth trajectory hugely and created much greater inequality."

The second wave presents difficult choices for India and Mr. Modi. India on Friday reported more than 216,000 new infections, another record. Lockdowns are back in some states. With work scarce, migrant workers are packing into trains and buses home as they did last year. The country's vaccination campaign has been slow, though the government has picked up the pace. Yet Mr. Modi appears unwilling to repeat last year's draconian lockdown, which left more than 100 million Indians jobless and which many economists blame for worsening the pandemic's problems. His government has also been reluctant to increase spending substantially like the United States and some other places, instead releasing a budget that would raise spending on infrastructure and in other areas but that also emphasizes cutting debt.

Slashdot reader quonset reminds us that NASA's Mars helicopter "is officially 'go' for flight!," according to the Twitter feed of the Perserverance Rover, which notes that its cameras are ready to film the historic event.

"Watch with the team as they receive data and find out if they were successful," adds NASA's official feed. "Meet us in mission control April 19 at 6:15am ET (10:15am UTC): Data from the first flight will return to Earth a few hours following the autonomous flight. A livestream will begin at 6:15 a.m. EDT (3:15 a.m. PDT), as the helicopter team prepares to receive the data downlink in the Space Flight Operations Facility at NASA's Jet Propulsion Laboratory (JPL). Watch on NASA Television, the agency app, website, and social media platforms, including YouTube and Facebook.

If the flight takes place April 19, a postflight briefing will be held at 2 p.m. EDT (11 a.m. PDT)...

The public and media also may ask questions on social media during the livestream and briefing using #MarsHelicopter. Find the latest schedule updates here.

The Perseverance rover will provide support during flight operations, taking images, collecting environmental data, and hosting the base station that enables the helicopter to communicate with mission controllers on Earth.
Update: And it's a success! "We've been talking for so long about our Wright Brothers moment on Mars, and here it is," said NASA Ingenuity Mars Helicopter project manager MiMi Aung. The Perserverance rover has already tweeted out a choppy video.

"Two satellites from the fast-growing constellations of OneWeb and SpaceX's Starlink dodged a dangerously close approach with one another in orbit," reported The Verge, citing representatives from both OneWeb and the U.S. Space Force.

UPDATE (April 22): SpaceX strongly disputes OneWeb's characterization of the event.

Below is the Verge's original report: On March 30th, five days after OneWeb launched its latest batch of 36 satellites from Russia, the company received several "red alerts" from the US Space Force's 18th Space Control Squadron warning of a possible collision with a Starlink satellite. Because OneWeb's constellation operates in higher orbits around Earth, the company's satellites must pass through SpaceX's mesh of Starlink satellites, which orbit at an altitude of roughly 550 km.

One Space Force alert indicated a collision probability of 1.3 percent, with the two satellites coming as close as 190 feet — a dangerously close proximity for satellites in orbit. If satellites collide in orbit, it could cause a cascading disaster that could generate hundreds of pieces of debris and send them on crash courses with other satellites nearby...

Space Force's urgent alerts sent OneWeb engineers scrambling to email SpaceX's Starlink team to coordinate maneuvers that would put the two satellites at safer distances from one another. While coordinating with OneWeb, SpaceX disabled its automated AI-powered collision avoidance system to allow OneWeb to steer its satellite out of the way, according to OneWeb's government affairs chief Chris McLaughlin... SpaceX's automated system for avoiding satellite collisions has sparked controversy, raising concerns from other satellite operators who say they have no way of knowing which way the system will move a Starlink satellite in the event of a close approach.

Aflorithmic, an AI-driven audio cloning startup, has created a digital version of Albert Einstein using AI voice cloning technology drawing on audio records of the famous scientist's actual voice. TechCrunch reports: Alforithmic says the "digital Einstein" is intended as a showcase for what will soon be possible with conversational social commerce. Which is a fancy way of saying deepfakes that make like historical figures will probably be trying to sell you pizza soon enough, as industry watchers have presciently warned. The startup also says it sees educational potential in bringing famous, long-deceased figures to interactive "life." Or, well, an artificial approximation of it -- the "life" being purely virtual and Digital Einstein's voice not being a pure tech-powered clone either; Alforithmic says it also worked with an actor to do voice modelling for the chatbot (because how else was it going to get Digital Einstein to be able to say words the real-deal would never even have dreamt of saying -- like, er, "blockchain"?). So there's a bit more than AI artifice going on here too.

In a blog post discussing how it recreated Einstein's voice the startup writes about progress it made on one challenging element associated with the chatbot version -- saying it was able to shrink the response time between turning around input text from the computational knowledge engine to its API being able to render a voiced response, down from an initial 12 seconds to less than three (which it dubs "near-real-time"). But it's still enough of a lag to ensure the bot can't escape from being a bit tedious. The report notes that the video engine powering the 3D character rendering components of this "digital human" version of Einstein is the work of another synthesized media company, UneeQ, which is hosting the interactive chatbot version on its website.

AmiMoJo shares a report from The Guardian: The whitest-ever paint has been produced by academic researchers, with the aim of boosting the cooling of buildings and tackling the climate crisis. The new paint reflects 98% of sunlight as well as radiating infrared heat through the atmosphere into space. In tests, it cooled surfaces by 4.5C below the ambient temperature, even in strong sunlight. The researchers said the paint could be on the market in one or two years. Currently available reflective white paints are far better than dark roofing materials, but only reflect 80-90% of sunlight and absorb UV light. This means they cannot cool surfaces below ambient temperatures. The new paint does this, leading to less need for air conditioning and the carbon emissions they produce, which are rising rapidly.

The new paint was revealed in a report in the journal ACS Applied Materials & Interfaces. Three factors are responsible for the paint's cooling performance. First, barium sulphate was used as the pigment which, unlike conventional titanium dioxide pigment, does not absorb UV light. Second, a high concentration of pigment was used -- 60%. Third, the pigment particles were of varied size. The amount of light scattered by a particle depends on its size, so using a range scatters more of the light spectrum from the sun. The researchers said the ultra-white paint uses a standard acrylic solvent and could be manufactured like conventional paint. They claim the paint would be similar in price to current paints, with barium sulphate actually cheaper than titanium dioxide. They have also tested the paint's resistance to abrasion, but said longer-term weathering tests were needed to assess its long-term durability.

NASA on Friday selected SpaceX to build spacecraft that would land astronauts on the moon for the first time since the last Apollo mission, according to a source selection document obtained by The Washington Post. From the report: The contract marks another major victory for the hard-charging company that vaults it to the top tier of the nation's aerospace companies and solidifies it as one of the space agency's most trusted partners. In winning the $2.9 billion contract, SpaceX beat out Jeff Bezos' Blue Origin, which had formed what it called a "national team" by partnering with aerospace giants Lockheed Martin, Northrop Grumman and Draper. SpaceX also won over Dynetics, a defense contractor based in Huntsville, Ala. NASA had originally chosen all three companies for the initial phase of the contract, and was expected to choose two of them to build the lunar lander. In other major programs, NASA has chosen multiple providers to foster competition and to ensure it has redundancy in case one can't deliver. But in choosing SpaceX alone, it sent a message that it fully trusts the growing company to fly its astronauts for its signature human exploration program -- Artemis, a campaign to return astronauts to the moon for the first time since 1972.

For the first time, scientists have estimated how many Tyrannosaurus rex, the so-called king of dinosaurs, once roamed the Earth. From a report: The number is staggering: 2.5 billion Tyrannosaurus rex lived and died during the roughly 2.4 million years the species survived on the planet, according to a new study set to be published in the journal Science on Friday. The study may help contextualize the fossil record and the rarity of finding certain fossilized prehistoric organisms, according to lead researcher Charles Marshall, director of the University of California Museum of Paleontology. "I mean, to me, it's just amazing we could have come up with a number," Marshall told Axios. "Some people have asked me, 'How does your number compare to other numbers of the total that have ever lived?' The answer is it doesn't because there weren't any."

Pfizer CEO Albert Bourla said people will "likely" need a booster dose of a Covid-19 vaccine within 12 months of getting fully vaccinated. His comments were made public Thursday but were taped April 1. From a report: Bourla said it's possible people will need to get vaccinated against the coronavirus annually. "A likely scenario is that there will be likely a need for a third dose, somewhere between six and 12 months and then from there, there will be an annual revaccination, but all of that needs to be confirmed. And again, the variants will play a key role," he told CNBC's Bertha Coombs during an event with CVS Health. "It is extremely important to suppress the pool of people that can be susceptible to the virus," Bourla said. The comment comes after Johnson & Johnson CEO Alex Gorsky told CNBC in February that people may need to get vaccinated against Covid-19 annually, just like seasonal flu shots. Researchers still don't know how long protection against the virus lasts once someone has been fully vaccinated.

An anonymous reader quotes a report from Ars Technica: Cases of COVID-19 are extremely rare among people who are fully vaccinated, according to a new data analysis by the Centers for Disease Control and Prevention. Among more than 75 million fully vaccinated people in the US, just around 5,800 people reported a "breakthrough" infection, in which they became infected with the pandemic coronavirus despite being fully vaccinated. The numbers suggest that breakthroughs occur at the teeny rate of less than 0.008 percent of fully vaccinated people -- and that over 99.992 percent of those vaccinated have not contracted a SARS-CoV-2 infection.

The figures come from a nationwide database that the CDC set up to keep track of breakthrough infections and monitor for any concerning signs that the breakthroughs may be clustering by patient demographics, geographic location, time since vaccination, vaccine type, or vaccine lot number. The agency will also be keeping a close eye on any breakthrough infections that are caused by SARS-CoV-2 variants, some of which have been shown to knock back vaccine efficacy. [...] The extraordinary calculation that 99.992 percent of vaccinated people have not contracted the virus may reflect that they all simply have not been exposed to the virus since being vaccinated. Also, there are likely cases missed in reporting. Still, the data is a heartening sign. As for the "breakthroughs," the agency says many of them occurred in older people, who are more vulnerable to COVID-19. There are some scattered through every age group, but more than 40 percent were in people ages 60 and above.

"We see [breakthroughs] with all vaccines," top infectious disease expert Anthony Fauci said in a press briefing earlier this week. "No vaccine is 100 percent efficacious or effective, which means that you will always see breakthrough infections regardless of the efficacy of your vaccine."

California and its partners are set to launch by 2023 two satellites to spot and monitor plumes of planet-warming carbon dioxide (CO2) and methane. "If all goes right, dozens more could follow," reports Science Magazine. From the report: The $100 million Carbon Mapper project, announced today and financed by private philanthropists including Michael Bloomberg, will advance efforts to track concentrated emissions of greenhouse gases, which rise from fossil fuel power plants, leaky pipelines, and abandoned wells. Previous satellites have lacked the resolution and focus to monitor point sources rigorously. [...] The satellites will be built and managed by Planet, a California company that already operates a constellation of Earth-imaging satellites. The spacecraft will rely on "hyperspectral" imaging spectrometers developed by NASA's Jet Propulsion Laboratory (JPL). Rather than gathering light in just a few discrete wavelength channels, like the human eye, these spectrometers capture reflected sunlight and subdivide it into more than 400 wavelength channels across the visible and into the infrared. The intensity of light across these channels can be tied to specific chemistries and reflect the abundances of certain gases in the air molecules below.

The satellites won't just measure gases in the air; they will also detect chemical signatures on the ground. By measuring the intensity of green chlorophyll or detecting the signatures for excess salts or fungus, for example, researchers will be able to evaluate the health of crops and forests. They can prospect for minerals in remote regions. They can map and identify different coral and algae species, and they can track dust and soot. Even snow and ice pops out in these sensors, says Robert Green, a remote-sensing scientist at JPL. "Snow is one of the most colorful materials on Earth if you look beyond visible light."

The first two Carbon Mapper satellites will each be roughly the size of a washing machine, weighing up to 200 kilograms. They will provide imagery with a resolution of 30 meters but won't offer global coverage at first. Instead, they will target regions known to host superemitters, like power plants, oil and gas drilling, or livestock operations. The regions will be revisited every few weeks to start. All emission data, calculated from the plume intensity and length, will be made publicly available -- in the hopes that governments and businesses will do more to staunch leaks and tamp down discharges. [...] Should Carbon Mapper's first two satellites prove successful, Planet envisions building a commercial constellation of similar satellites that would revisit every spot on the planet once a day, and selling those data to regulators and companies.

Researchers at the University of Washington have partnered with Apple to study how Apple Watch may be used to predict illnesses such as coronavirus, or flu. Apple Insider reports: "The goal of the study is to see if the information collected by the Apple Watch and iPhone can detect early signs of respiratory illnesses like COVID-19," say the organizers on the recruitment page. The study is focusing on the Seattle area because residents "may have higher than normal risk of respiratory illness because of frequent exposure to other people through work or other activities, health conditions, or other factors."

This Apple Respiratory Study is expected to take "up to six months." During the study, participants will be required to periodically answer survey questions in the Apple Research iPhone app. If participants get sick while enrolled in the study, they will be sent an in-home testing kit for COVID-19 and other respiratory illnesses. But, this will likely assist the study further, as sick participants will be asked to "take some additional health measurements using your Apple Watch."

If your heart stops en route to Mars, rest assured that researchers have considered how to carry out CPR in space. (One option is to plant your feet on the ceiling and extend your arms downwards to compress the patient's chest.) From a report: Astronauts, because of their age range and high physical fitness, are unlikely to suffer a stroke or have their appendix suddenly explode. That's good because, if it does happen, they're in the realm of what Jonathan Scott -- head of the medical projects and technology team at the European Space Agency -- describes as 'treatment futility.' In other words: there's nothing anyone can do about it. On the ISS, when medical incidents arise, astronauts can draw on the combined expertise of a host of medical experts at Nasa. "The patient is on the space station, the doctor is on the ground, and if there's a problem the patient consults the doctor," says Scott. By the time astronauts reach Mars, there'll be a 40-minute time lag in communications, if it's possible to make contact at all. "We have to begin preparing for not only being able to diagnose things in spaceflight but also to treat them as well," Scott says.

Artificial intelligence is likely to be a part of the solution. If you're imagining the holographic doctor from Star Trek, downgrade your expectations, at least for the next few decades. Kris Lehnhardt, the element scientist for exploration medical capability at Nasa, says: "We are many, many, many years away from: please state the nature of the medical emergency." Emmanuel Urquieta is deputy chief scientist at the Translational Institute for Space Health (TRISH), a Nasa-funded program which conducts research into healthcare for deep space missions. While full AI may be a way off, Urquieta believes some form of artificial intelligence will still play a crucial role. "It's going to be essential for a mission to Mars," he says. While the crew for a mission to Mars will likely include a medical doctor, he explains: "No single physician can know everything." And, of course: "What happens if that astronaut gets sick?" Research projects funded by TRISH include Butterfly iQ, a handheld ultrasound device for use by non-medical personnel to make diagnoses that would otherwise require bulky equipment and a trained operator. VisualDx is an AI diagnostics tool originally developed to analyse images and identify skin conditions. The technology is now being adapted to help astronauts diagnose a wide range of conditions most commonly encountered in space, without an internet connection.

Slashdot reader omfglearntoplay shares an excerpt from a BBC article that explores the new technologies that may have already introduced genetic errors to the human gene pool. The article starts by mentioning He Jiankui, a Shenzhen researcher who was sentenced to prison in late 2019 for creating the world's first genetically altered babies. From the report: Jiankui had made the first genetically modified babies in the history of humankind. After 3.7 billion years of continuous, undisturbed evolution by natural selection, a life form had taken its innate biology into its own hands. The result was twin baby girls who were born with altered copies of a gene known as CCR5, which the scientist hoped would make them immune to HIV. But things were not as they seemed. In the years since, it's become clear that Jiankui's project was not quite as innocent as it might sound. He had broken laws, forged documents, misled the babies' parents about any risks and failed to do adequate safety testing. However, arguably the biggest twist were the mistakes. It turns out that the babies involved, Lulu and Nana, have not been gifted with neatly edited genes after all. Not only are they not necessarily immune to HIV, they have been accidentally endowed with versions of CCR5 that are entirely made up -- they likely do not exist in any other human genome on the planet. And yet, such changes are heritable -- they could be passed on to their children, and children's children, and so on.

In fact, there have been no shortage of surprises in the field. From the rabbits altered to be leaner that inexplicably ended up with much longer tongues to the cattle tweaked to lack horns that were inadvertently endowed with a long stretch of bacterial DNA in their genomes (including some genes that confer antibiotic resistance, no less) -- its past is riddled with errors and misunderstandings. More recently, researchers at the Francis Crick Institute in London warned that editing the genetics of human embryos can lead to unintended consequences. By analyzing data from previous experiments, they found that approximately 16% had accidental mutations that would not have been picked up via standard tests. Why are these mistakes so common? Can they be overcome? And how could they affect future generations?

fahrbot-bot shares a report from Phys.Org: Why is sugar not transparent? Because light that penetrates a piece of sugar is scattered, altered and deflected in a highly complicated way. However, as a research team from TU Wien (Vienna) and Utrecht University (Netherlands) has now been able to show, there is a class of very special light waves for which this does not apply: for any specific disordered medium -- such as the sugar cube you may just have put in your coffee -- tailor-made light beams can be constructed that are practically not changed by this medium, but only attenuated. The light beam penetrates the medium, and a light pattern arrives on the other side that has the same shape as if the medium were not there at all. This idea of "scattering-invariant modes of light" can also be used to specifically examine the interior of objects. The results have now been published in the journal Nature Photonics. This method of finding light patterns that penetrate an object largely undisturbed could also be used for imaging procedures. "In hospitals, X-rays are used to look inside the body -- they have a shorter wavelength and can therefore penetrate our skin. But the way a light wave penetrates an object depends not only on the wavelength, but also on the waveform," says Matthias Kuhmayer, who works as a Ph.D. student on computer simulations of wave propagation. "If you want to focus light inside an object at certain points, then our method opens up completely new possibilities. We were able to show that using our approach the light distribution inside the zinc oxide layer can also be specifically controlled."

An anonymous reader quotes a report from ScienceAlert: [T]here's been a longstanding question over whether heavy water tastes the same as regular drinking water -- or whether its subtle isotopic variation yields a different taste that people may be able to perceive. "There is anecdotal evidence from the 1930s that the taste of pure D2O is distinct from the neutral one of pure H2O, being described mostly as 'sweet,'" an international team of researchers led by first authors and biochemists Natalie Ben Abu and Philip E. Mason explains in a new study. [I]n their new research, Ben Abu, Mason, and their team can finally confirm that there really is something a bit different about the taste of heavy water. "Despite the fact that the two isotopes are nominally chemically identical, we have shown conclusively that humans can distinguish by taste (which is based on chemical sensing) between H2O and D2O, with the latter having a distinct sweet taste," explains senior author and physical chemist Pavel Jungwirth from the Czech Academy of Sciences.

In a taste-testing experiment with 28 participants, most people were able to distinguish between H2O and D2O, and tests with mixed amounts of the waters revealed that greater proportions of heavy water were perceived as tasting sweeter. In tests with mice, however, the animals did not seem to prefer drinking heavy water over regular water, although they did show a preference for sugared water -- suggesting that in mice, D2O does not elicit the same sweet taste that people can perceive. Other taste tests conducted by the team suggest why this is so, indicating that human taste receptivity to D2O is mediated by the taste receptor TAS1R2/TAS1R3, which is known to respond to sweetness in both natural sugars and artificial sweeteners. Experiments in the lab with HEK 293 cells confirmed the same thing, showing robust responses in TAS1R2/TAS1R3 expressing cells when exposed to D2O. The findings are published in the journal Communications Biology.

Sixty years ago today, Yuri Gagarin became the first human ever in space.

Space.com reports: Because no one was certain how weightlessness would affect a pilot, the spherical capsule had little in the way of onboard controls; the work was done either automatically or from the ground. If an emergency arose, Gagarin was supposed to receive an override code that would allow him to take manual control, but Sergei Korolev, chief designer of the Soviet space program, disregarded protocol and gave the code to the pilot prior to the flight.

Over the course of 108 minutes, Vostok 1 traveled around the Earth once, reaching a maximum height of 203 miles (327 kilometers). The spacecraft carried 10 days' worth of provisions in case the engines failed and Gagarin was required to wait for the orbit to naturally decay. But the supplies were unnecessary. Gagarin re-entered Earth's atmosphere, managing to maintain consciousness as he experienced forces up to eight times the pull of gravity during his descent.
The BBC remembers how on his return to earth, Gagarin parachuted into some farmland several hundred miles from Moscow — "much to the surprise of a five-year-old girl who was out in the fields planting potatoes."

60 years later, the BBC tracked down and interviewed Interviewed that woman — who still remembered Gagarin's kind voice and smile. (Thanks to Slashdot reader 4wdloop for sharing the article.)

The BBC also published a look at Gagarin's global fame in the years that followed — and Phys.org notes that even today, there are few people more universally admired in Russia than Yuri Gagarin: His smiling face adorns murals across the country. He stands, arms at his sides as if zooming into space, on a pedestal 42.5 metres (140 feet) above the traffic flowing on Moscow's Leninsky Avenue. He is even a favourite subject of tattoos... The anniversary of Gagarin's historic flight on April 12, 1961 — celebrated every year in Russia as Cosmonautics Day — sees Russians of all ages lay flowers at monuments to his accomplishment across the country...

Gagarin, says historian Alexander Zheleznyakov, was a figure who helped fuel the imagination. "He transformed us from a simple biological species to one that could imagine an entire universe beyond Earth."

Long-time Slashdot reader destinyland writes: The New York Times tells the story of Hungarian-born Dr. Kariko, whose father was a butcher and who growing up had never met a scientist — but knew they wanted to be one. Despite earning a Ph.D. at Hungary's University of Szeged and working as a postdoctoral fellow at its Biological Research Center, Kariko never found a permanent position after moving to the U.S., "instead clinging to the fringes of academia."

Now 66 years old, Dr. Kariko is suddenly being hailed as "one of the heroes of Covid-19 vaccine development," after spending an entire career focused on mRNA, "convinced mRNA could be used to instruct cells to make their own medicines, including vaccines."
From the article: For many years her career at the University of Pennsylvania was fragile. She migrated from lab to lab, relying on one senior scientist after another to take her in. She never made more than $60,000 a year... She needed grants to pursue ideas that seemed wild and fanciful. She did not get them, even as more mundane research was rewarded. "When your idea is against the conventional wisdom that makes sense to the star chamber, it is very hard to break out," said Dr. David Langer, a neurosurgeon who has worked with Dr. Kariko... Kariko's husband, Bela Francia, manager of an apartment complex, once calculated that her endless workdays meant she was earning about a dollar an hour.
The Times also describes a formative experience in 1989 with cardiologist Elliot Barnathan: One fateful day, the two scientists hovered over a dot-matrix printer in a narrow room at the end of a long hall. A gamma counter, needed to track the radioactive molecule, was attached to a printer. It began to spew data.

Their detector had found new proteins produced by cells that were never supposed to make them — suggesting that mRNA could be used to direct any cell to make any protein, at will.

"I felt like a god," Dr. Kariko recalled.
Yet Kariko was eventually left without a lab or funds for research, until a chance meeting at a photocopying machine led to a partnership with Dr. Drew Weissman of the University of Pennsylvania: "We both started writing grants," Dr. Weissman said. "We didn't get most of them. People were not interested in mRNA. The people who reviewed the grants said mRNA will not be a good therapeutic, so don't bother.'" Leading scientific journals rejected their work. When the research finally was published, in Immunity, it got little attention... "We talked to pharmaceutical companies and venture capitalists. No one cared," Dr. Weissman said. "We were screaming a lot, but no one would listen."

Eventually, though, two biotech companies took notice of the work: Moderna, in the United States, and BioNTech, in Germany. Pfizer partnered with BioNTech, and the two now help fund Dr. Weissman's lab.

"Astrophysicists have found a new region of the Milky Way, and it's filled with searingly hot, bright-blue stars that are about to explode," writes Live Science (in a report shared by long-time Slashdot reader fahrbot-bot): The researchers were creating the most detailed map yet of the star-flecked spiral arms of our galactic neighborhood with the European Space Agency's (ESA) Gaia telescope when they discovered the region, which they have named the Cepheus spur, they reported in a new study.

Nestled between the Orion Arm — where our solar system is — and the constellation Perseus, the spur is a belt between two spiral arms filled with enormous stars three times the size of the sun and colored blue by their blistering heat. Astronomers call these giant, blue stars OB stars due to the predominantly blue wavelengths of light that they emit. They are the rarest, hottest, shortest-living and largest stars in the entire galaxy. The violent nuclear reactions taking place inside their hearts make them six times hotter than the sun. And the enormous stellar explosions that end their lives — called supernovas — scatter the heavy elements essential for complex life far into the galaxy.

"OB stars are rare, in a Galaxy of 400 billion stars there might be less than 200,000," study co-author Michelangelo Pantaleoni González, a researcher at the Spanish Astrobiology Center (CAB), told Live Science.

An anonymous reader shares this announcement from NASA: Based on data from the Ingenuity Mars helicopter that arrived late Friday night, NASA has chosen to reschedule the Ingenuity Mars Helicopter's first experimental flight to no earlier than April 14 [this Wednesday].

During a high-speed spin test of the rotors on Friday, the command sequence controlling the test ended early due to a "watchdog" timer expiration. This occurred as it was trying to transition the flight computer from 'Pre-Flight' to 'Flight' mode. The helicopter is safe and healthy and communicated its full telemetry set to Earth.

The watchdog timer oversees the command sequence and alerts the system to any potential issues. It helps the system stay safe by not proceeding if an issue is observed and worked as planned.

The helicopter team is reviewing telemetry to diagnose and understand the issue. Following that, they will reschedule the full-speed test.